Selected Publications:
Sadri-Gerrior, M., Shivakumar, K., Rouleau, N. (2025, In Press). Cultural Considerations of Suicide Risk Assessment with Immigrant Populations in Canada. Transcultural Psychiatry.
Casey, H., DiBerardino, I., Bonzanni, M., Rouleau, N., Murugan, N.J. (2025). Exploring ultraweak photon emissions as optical markers of brain activity. iScience. 28(3), 112019. https://doi.org/10.1016/j.isci.2025.112019
Rouleau, N., and Murugan, N. (2025). The risks and rewards of embodying AI with cloud-based laboratories. Advanced Intelligent System. 7(1), 2400193. https://doi.org/10.1002/aisy.202400193
Martel, J., Rouleau, N., Murugan, N.J., Chin W.C., Ojcius, D.M., Young, J.D. (2024). Effects of light, electromagnetic fields and water on biological rhythms. Biomedical Journal. 100824. https://doi.org/10.1016/j.bj.2024.100824
Rouleau, N., and Levin, M. (2024) Discussions of machine versus living intelligence need more clarity. Nature Machine Intelligence. 6(12), 1424–1426. https://doi.org/10.1038/s42256-024-00955-y
Murugan, N.J., Cariba, S., Abeygunawardena, S., Rouleau, N., Payne, S.L. (2024). Biophysical control of plasticity and patterning in regeneration and cancer. Cellular and Molecular Life Sciences. 81(1), 1-9. https://doi.org/10.1007/s00018-023-05054-6
Rouleau, N., and Levin, M. (2023). The multiple realizability of sentience in living systems and beyond. eNeuro. 10(11), 1-7. https://doi.org/10.1523/ENEURO.0375-23.2023
Rouleau, N., and Murugan, N.J. (2023). Self-similarity and spatial periodicity in cerebral cortical patterning: Structural design notes for neural tissue architects. Anatomia. 2(3), 222-231. https://doi.org/10.3390/anatomia2030020
Rouleau, N. & Levin, M. (2023) Multiple ways to implement and infer sentience. Animal Sentience. 33(30), 1-3. https://doi.org/10.51291/2377-7478.1817
Lomoio, S., Pandey, R.S., Rouleau, N., Manicacci, B., Kim, W.H., Cantley, W.L., Haydon, PG., Bennett, D.A., Young-Pearse, T.L., Carter, G.W., Kaplan, D.L., and Tesco, G. (2023). 3D bioengineered neural tissue generated from patient-derived iPSCs mimics time-dependent phenotypes and transcriptional features of Alzheimer’s disease. Molecular Psychiatry. 28, 5390-5401. https://doi.org/10.1038/s41380-023-02147-3
Rouleau, N., Murugan, N., and Kaplan, D.L. (2023). Functional bioengineered models of the central nervous system. Nature Reviews Bioengineering. 1(2), 1-19. https://doi.org/10.1038/s44222-023-00027-7
Rouleau, N. & Cimino, N. (2022). A Transmissive Theory of Brain Function: Implications for Health, Disease, and Consciousness. NeuroSci. 3(3),440-456. https://doi.org/10.3390/neurosci3030032
Rouleau, N., Cairns, D., Rusk, W., Levin, M., Kaplan, D.L. (2021). Learning and Synaptic Plasticity in 3D Bioengineered Neural Tissues. Neuroscience Letters. 750, 135799. https://doi.org/10.1016/j.neulet.2021.135799
Rouleau, N., Murugan, N.J., and Kaplan, D.L. (2021). Toward Studying Cognition in a Dish. Trends in Cognitive Sciences. 25(4), 294-304. https://doi.org/10.1016/j.tics.2021.01.005
Rouleau, N., Bonzanni, M., Erndt-Marino, J., Sievert, K., Ramirez, C.G., Rusk, W., Levin, M., Kaplan. D.L. (2020). A 3D Tissue Model of Traumatic Brain Injury with Excitotoxicity that is Inhibited by Chronic Exposure to Gabapentinoids. Biomolecules. 10(8), 1196. https://doi.org/10.3390/biom10081196
Rouleau, N., Murugan, N.J., Rusk, W., Koester, C., Kaplan, D.L. (2020). Matrix Deformation with Ectopic Cells Induced by Rotational Motion in Bioengineered Neural Tissues. Annals of Biomedical Engineering. 48, 2192-2203. https://doi.org/10.1007/s10439-020-02561-6
Liaudanskaya, V., Chung, J.Y., Mizzoni, C., Rouleau, N., Berk, A.N., Wu, L., Turner, J.A., Georgiakoudi, I., Whalen, M.J., Nieland, T.J.F., and Kaplan, D.L. (2020). Modeling Controlled Cortical Impact Injury in 3D Brain‐Like Tissue Cultures. Advanced Healthcare Materials. 23(8), 1-14. https://doi.org/10.1002/adhm.202000122
Cairns, D., Rouleau, N., Parker, R.N., Walsh, K.G., Gehrke, L., and Kaplan, D.L. (2020). A 3D Human Brain-Like Model of Herpes-Induced Alzheimer’s Disease. Science Advances. 6(19), eaay8828. https://doi.org/10.1126/sciadv.aay8828
Rouleau, N., Cantley, W.L., Liaudanskaya, V., Berk, A., Du C., Rusk, W., Peirent, E., Koester, C., Nieland, T.J.F., & Kaplan, D.L. (2020). A Long-Living Bioengineered Neural Tissue Platform to Study Neurodegeneration. Macromolecular Biosciences 20(3). https://doi.org/10.1002/mabi.202000004
Bonzanni, M., Rouleau, N., Levin, M., Kaplan, D.L. (2020). Optogenetically Induced Cellular Habituation in Non-Neuronal Cells. PLoS ONE. 15(1): e0227230. https://doi.org/10.1371/journal.pone.0227230
Bonzanni, M., Rouleau, N., Levin, M., and Kaplan, D.L. (2019). On the Generalization of Habituation: How Discrete Biological Systems Respond to Repetitive Stimuli. BioEssays. 41(7), 1-8. https://doi.org/10.1002/bies.201900028
Collins W., Rouleau, N., Bonzanni, M., Kapner, K., Mizzoni, C., Jeremiah, A., Du, C., Pothos, E., Nieland, T., Kaplan, D.L. (2018). Functional Effects of Neuromelanin and Iron Neuromelanin Precipitate on Local Field Potential Measurements of Dopaminergic Neurons in 3D Silk Scaffolding. ACS Biomaterials Science and Engineering. 5(1), 308-317. https://doi.org/10.1021/acsbiomaterials.8b00976
Murugan, N.J., Rouleau, N., Karbowski, L.M., Persinger, M.A. (2018). Biophotonic Markers of Malignancy: Discriminating Cancers Using Wavelength-Specific Biophotons. Biochemistry and Biophysics Reports, 13, 7-11. https://doi.org/10.1016/j.bbrep.2017.11.001
Rouleau, N., Murugan N.J., & Persinger, M.A. (2017). Right Cerebral Hemispheric Sensitivity to pH and Physiological Ions in Fixed Post-Mortem Wistar Rat Brains. Cognitive Neurodynamics, 11, 1-10. https://doi.org/10.1007/s11571-017-9443-3
Rouleau, N. & Persinger, M.A. (2017) Neural Tissues Filter Electromagnetic Fields: Investigating Regional Processing of Induced Current in ex vivo Brain Specimens. Biology and Medicine. 9(2), 1-7. https://doi.org/10.4172/0974-8369.1000392
Rouleau, N., Costa, J.N., & Persinger, M.A. (2017). Evaluating the Signal Processing Capacities of Post-Mortem Cerebral Cortical Tissue by Artificial Phototransduction of Dynamic Visual Stimuli. Open Journal of Biophysics. 7, 1-13. https://doi.org/10.4236/ojbiphy.2017.71001
Rouleau, N., Murugan, N.J., Tessaro, L.W.E., Costa, J.N., & Persinger, M.A. (2016). When is the Brain Dead? Living-Like Responses to Neurotransmitters and Photon Emissions in Fixed Post-Mortem Human Brains. PLoS ONE. 11(12): e0167231. https://doi.org/10.1371/journal.pone.0167231
Rouleau, N., Reive, B.S., & Persinger, M.A. (2016). Functional Neuroimaging of Post-Mortem Tissue: Lithium-Pilocarpine Seized Rats Express Reduced Brain Mass and Proportional Reductions of Left Ventral Cerebral Theta Spectral Power. Heliyon. 2(10), 1-10. https://doi.org/10.1016/j.heliyon.2016.e00181
Rouleau, N., Karbowski, L., & Persinger, M.A. (2016). Experimental Evidence of Classical Conditioning and Microscopic Engrams in an Electroconductive Material. PLoS ONE. 0165269, 1-16. https://doi.org/10.1371/journal.pone.0165269
Costa, J., Rouleau, N., & Persinger, M.A. (2016). Differential Spontaneous Photon Emissions from Cerebral Hemispheres of Fixed Human Brains: Asymmetric Coupling to Geomagnetic Activity and Potentials for Examining Post-Mortem Intrinsic Photon Information. Neuroscience & Medicine. 7, 49-59. https://doi/org/10.4236/nm.2016.72006
Rouleau, N., Lehman, B., & Persinger, M.A. (2016). Focal Attenuation of Specific Electroencephalographic Power Over the Right Parahippocampal Region During Transcerebral Copper Screening in Living Subjects and Hemispheric Asymmetric Voltages in Fixed Coronal Sections. Brain Research. 1644, 267-277. https://doi.org/10.1016/j.brainres.2016.05.034
Rouleau, N. & Persinger, M.A. (2016). Differential Responsiveness of the Right Parahippocampal Region to Electrical Stimulation in Fixed Human Brains: Implications for Historical Surgical Stimulation Studies?. Epilepsy & Behavior. 60,181-186. https://doi.org/10.1016/j.yebeh.2016.04.028
Murugan, N.J., Rouleau, N., Karbowski, L.M., Lapointe, A.P., & Persinger, M. (2015). Reliable Marked Increases in Alpha Power Over the Left Prefrontal Region During Days Following Shift Work: A Case History. Journal of Sleep Disorder & Management, 1(1), 1-4.
Rouleau, N. & Dotta, B.T. (2014). Electromagnetic Fields as Structure-Function Zeitgebers in Biological Systems: Environmental Orchestrations of Morphogenesis and Consciousness. Frontiers in Integrative Neuroscience, 8(84), 1-9. https://doi.org/10.3389/fnint.2014.00084